The Ketogenic Diet
Modern variants of the ketogenic diet
Fatty acids, lipids and oils
KetoVOLVE™ is the brand name given to Nutr-e-volution’s range of ketogenic products.
KetoVOLVE™ came into being as a concept early in 2008 when Nutr-e-volution identified the need for an alternative ketogenic formula, following consultation with leading specialists in the neurology field. The development of KetoVOLVE™ commenced at the end of 2008. After the nutritional profile was finalised, the real work started. After several dozen trials and formulation revisions, Nutr-e-volution undertook initial efficacy and safety tests in August 2009.
The results were all positive and KetoVOLVE worked fantastically. What followed was a controlled cross-over trial performed to ensure and validate efficacy. Once again, KetoVOLVE excelled.
The first KetoVOLVE™ product, KetoVOLVE™ 4:1 was launched in November 2009. (A nutritionally complete medical food suitable for enteral and oral feeding, the product has a milky flavour with a fatty note and is free of any preservatives and artificial sweeteners).
Its launch corresponded with the progressing of a
brand identity resulting in a new look and packaging.
KetoVOLVE™ 4:1 is contraindicated in individuals with certain metabolic deficiencies:
Pyruvate carboxylase deficiencies
Inborn errors of fat metabolism
KetoVOLVE™ 4:1 is a complete nutritional product suitable for the administration of the ketogenic diet. This being the case, it has the same precautions as the ketogenic diet, namely:
Failure to gain weight
Low grade acidosis
Hypoglycaemia (if the diet is initiated with a fast)
Possible formation of renal stones
The combination of product efficacy and branding found acceptance in the market and resulted in significant success across Latin America. Five years later, KetoVOLVE™ was re-launched in the US with new distribution partners. Expansion plans to other markets around the world are currently in the pipeline.
KetoVOLVE™ products combine several aspects of the Ketogenic diet, namely the classical and MCT oil diet. KetoVOLVE is formulated to be as clinically effective as possible. To this end, it contains specifically selected ingredients that contribute both nutritionally and clinically. For example, the protein selected is whey protein, which is a nutritionally complete protein containing levels of essential amino acids at levels that meet or exceed human dietary requirements. From a biochemical perspective, the whey protein is high in large neutral amino acids (LNAA). Among the LNAAs, there is a subgroup called branched chain amino acids that have liver support functionality and help stabilise ketosis.
The whey protein is a blend of different proteins with different components. Of interest to epilepsy patients is a protein called α-lactalbumin (ALAC) which was the focus of a 2011 study, performed on rats, where extended and regular intake of ALAC reduced seizure activity and increased seizure thresholds in specific syndrome models (Rita Citraro, 2011).
Functionally, the whey protein allows medical professionals to decrease meal intervals. Casein, the major component of cow’s milk is a protein that forms a gel in the stomach and which slows the digestion process, resulting in higher gastric clearance times ie the amount of time the food item is in the stomach. Whey protein does not form a gel, so it is easily digested and clears the stomach rapidly. As a result, feeding periods can be brought closer to each other to reduce the risk of hypoglycaemia.
The LCT oil in KetoVOLVE is a palm fruit oil containing all the essential fatty acids. The MCT oil component of KetoVOLVE is a fractionated coconut oil consisting exclusively of C8 and C10. The C10 has a powerful antiepileptic effect (Pishan Chang, 2012). Every 100g of KetoVOLVE contains 7g of Decanoic acid (C10).
KetoVOLVE 4:1 is particularly effective in the management of:
West syndrome/Infantile spasm
GLUT-1 Deficiency syndrome
Doose Syndrome/MAE - Myoclonic astatic epilepsy
Pyruvate Dehydrogenase deficiency
© KetoVOLVE 2015. All Rights Reserved.
PO Box 137 Glenvista 2058
+27 861 999 666
+27 865 367 181
© KetoVOLVE 2015. All Rights Reserved.